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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Disuse supersensitivity ： ウィキペディア英語版 Disuse supersensitivity Disuse supersensitivity, also pharmacological disuse supersensitivity, pharmacological denervation supersensitivity is the increased sensitivity by a postsynaptic cell because of decreased input by incoming axons, e.g, due to the exposure to an antagonist drug.〔Yarbrough GG, Phillis JW., "Supersensitivity of central neurons--a brief review of an emerging concept", Can J Neurol Sci. 1975 Aug;2(3):147-52. 〕〔Jaffe JH, Sharpless SK., "Pharmacological denervation supersensitivity in the central nervous system: a theory of physical dependence.", Res Publ Assoc Res Nerv Ment Dis. 1968;46:226-46. 〕 Jaffe anf Sharpless pointed out that withdrawal syndrome after the cessation of a chronically used drug often shows an exaggerated response which is normally suppressed by the drug which produced a dependence. They suggested the model according to which a drug has both excitatory and depressive effects. Depressive effects generate hypersensitivity, but at the same time they mask it. When drug usage stops, hypersensitivity becomes unmasked. 〔'Drug Addiction I: Morphine, Sedative/Hypnotic and Alcohol Dependence'', Springer Science & Business Media, 2013, ISBN 3642666124, (p. 636 )〕 ==References== 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Disuse supersensitivity」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.